2'-Hydroxyacetophenone

2'-Hydroxyacetophenone is also known as o-hydroxyacetophenone. Its molecular formula is C₈H₈O₂, which is a colorless and transparent liquid. The content of o-hydroxy group is derived from acetophenone. It is an important pharmaceutical and fine chemical intermediate. , Derived from the index. Mix phenol and acetyl chloride and slowly heat until hydrogen chloride stops escaping to obtain crude phenyl acetate. Add nitrobenzene, add aluminum trichloride under cooling, and stir at room temperature for 2-3h after the addition. Then pour into cold water and add 1: 3 hydrochloric acid until clear. Extract with diethyl ether, then recover the diethyl ether with the extract, and then perform steam distillation. Nitrobenzene and by-product o-hydroxyacetophenone are steamed off at any time, and p-hydroxyacetophenone remains in the residual liquid. The residue was extracted with diethyl ether, and the distillate was recovered after cooling the diethyl ether to obtain a crude product. The product was recrystallized from water. In the above acylation operation, acetic anhydride can be used instead of acetyl chloride, and phenol and acetic anhydride are heated under reflux for 3 hours to form phenyl acetate with a yield of about 83%. It can also be used without solvent under the action of anhydrous aluminum trichloride. In addition, p-aminoacetophenone can be diazotized with sodium nitrite and hydrolyzed to obtain p-hydroxyacetophenone.
 

2'-Hydroxyacetophenone Properties:

1. Properties: colorless transparent liquid.

2. Density (g / mL, 25 ° C): 1.131

3. Relative vapor density (g / mL, air = 1): 4.7

4. Melting point (ºC): 2.5

5. Boiling point (ºC, atmospheric pressure): 218; 90 ~ 95 (1.6kpa)

6. Boiling point (ºC, 2.3kPa): 106

7. Refractive index (n20D): 1.558

8. Flash point (ºC): 106

9. Relative density (20 ° C, 4 ° C): 1.1307

10. Relative density (25 ° C, 4 ° C): 1.1275

11. Vapor pressure (mmHg, 20ºC): ~ 0.2

12. Refractive index at normal temperature (n20): 1.5584

13. Refractive index at normal temperature (n25): 1.5564
 

Use of 2’-o-hydroxyacetophenone:

O-hydroxyacetophenone exists in the stems and leaves of Artemisia annua, Artemisia annua, Asteraceae, Ginseng vine, and other roots. It can be used as a raw material for synthesizing chalcone compounds. It has a wide range of uses in the development and industrial production of chemical products such as medicine and pesticides. It is a key intermediate for Xinluping, Propar Chemosterone, and choleretic drugs. It is widely used in the manufacture of choleretic drugs and Other organic synthetic raw materials.
 

2’-o-hydroxyacetophenone storage method:

Store in a cool, ventilated warehouse. Keep away from fire, heat and water. should be kept away from oxidizer, do not store together. Equipped with the appropriate variety and quantity of fire equipment. The storage area should be equipped with suitable materials to contain the spill and avoid contact with strong oxidants.
 

        2’-Hydroxyacetophenone Test Report