4'-Hydroxyacetophenone

4'-Hydroxyacetophenone, also known as p-hydroxyacetophenone, molecular formula C₈H₈O₂, molecular weight 136.15, white needle crystals at room temperature, flammable, easily soluble in hot water, methanol, ethanol, ether, acetone, benzene, difficult to dissolve Petroleum ether. It naturally exists in the stems and leaves of Asteraceae, Artemisia annua, and roots of plants such as Artemisia annua, Panax ginseng. This product is used to make bile medicine and other organic synthetic raw materials. Animal experiments show that this product can increase the secretion of bile in rats, and can also increase the amount of solids, bile acid, and bilirubin in bile. It also has the same effect on liver damage caused by carbon tetrachloride. This product is used clinically for the treatment of hepatitis and has a certain effect on fading. Therefore, it is harmful to swallow this product, and the contact will irritate the eyes, respiratory system and skin.
 

4′-hydroxyacetophenone manufacturing method:

The production of p-hydroxyacetophenone uses phenol as a raw material, which is obtained by acylation and translocation. Mix phenol with acetyl chloride, slowly heat until no hydrogen chloride is discharged, prepare phenyl acetate, add to nitrobenzene, add aluminum trichloride after cooling, stir for 2-3, then pour into cold water, add 1: 3 hydrochloric acid until cool, extract with ether, distill the ether out of the extract, distill off nitrobenzene and by-product o-hydroxyacetophenone by steam distillation, p-hydroxyacetophenone is left in the residue, Extraction and recrystallization gave the product.
 

4’-Hydroxyacetophenone Physical Properties

1. Appearance: white needle crystals at room temperature.

2. Boiling point: (° C) (760mmHg) 313 (399.9pa) 147-148

3. Melting point (° C) 107-111

4. Flash point: ℃ (closed) 121.2

5. Density: g / cm31.14

6. Refractive index: nD1091.5577

7. Vapor pressure: mmHg (° C) 0.000278 (25)

8. Solubility: soluble in hot water, methanol, ethanol, ether, acetone, benzene, hardly soluble in petroleum ether It is soluble in 100 parts of water at 22 ° C and 14 parts of water at 100 ° C.
 

4’-Hydroxyacetophenone Properties

[CAS login number] 99-93-4

[EINECS registration number] 202-802-8

[Molecular weight] 136.1479

[Molecular formula and structural formula] The molecular formula is C8H8O2, and the chemical structural formula is as follows:

[Common chemical reactions] Substitution reaction on benzene ring and related reaction performance of keto group.

[Incompatibility] Strong oxidant.

[Polymerization Hazard] No danger of polymerization
 

4’-Hydroxyacetophenone main uses:

P-hydroxyacetophenone itself is a choleretic drug and is often used as an adjunct to the treatment of cholecystitis and acute and chronic jaundice hepatitis, but the application must follow the doctor's order. In addition, p-hydroxyacetophenone is also a raw material for fine chemical synthesis, which is mostly used in the synthesis of perfumes.
 

Storage of 4'-hydroxyacetophenone:

Packed in rigid cardboard barrels lined with plastic film or kraft paper, stored in a cool, ventilated warehouse. Keep away from fire, heat and water. It should be stored separately from oxidants and foods.

 

Test report of 4’-hydroxyacetophenone white powder	Test report of 4’-hydroxyacetophenone white crystals